%0 Journal Article
%T Omega©\3 polyunsaturated fatty acid supplementation reduces blood pressure but not renal vasoconstrictor response to orthostatic stress in healthy older adults
%A Christine M. Clark
%A Kevin D. Monahan
%A Rachel C. Drew
%J Archive of "Physiological Reports".
%D 2018
%R 10.14814/phy2.13674
%X Older adults exhibit augmented renal vasoconstriction during orthostatic stress compared to young adults. Consumption of omega©\3 polyunsaturated fatty acids, such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) found in fish oil (FO), modulates autonomic nerve activity. However, the effect of omega©\3 polyunsaturated fatty acid consumption on the renal vasoconstrictor response to orthostatic stress in young and older adults is unknown. Therefore, 10 young (25 ¡À 1 years; mean ¡À SEM) and 10 older (66 ¡À 2 years) healthy adults ingested 4 g FO daily for 12 weeks, and underwent graded lower body negative pressure (LBNP; £¿15 and £¿30 mmHg) pre©\ and post©\FO supplementation. Renal blood flow velocity (RBFV; Doppler ultrasound), arterial blood pressure (BP; photoplethysmographic finger cuff), and heart rate (electrocardiogram) were recorded. Renal vascular resistance (RVR), an index of renal vasoconstriction, was calculated as mean BP/RBFV. All baseline cardiovascular values were similar between groups and visits, except diastolic BP was higher in the older group (P < 0.05). FO supplementation increased erythrocyte EPA and DHA content in both groups (P < 0.05). FO did not affect RVR or RBFV responses to LBNP in either group, but attenuated the mean BP response to LBNP in the older group (older £¿30 mmHg: pre©\FO £¿4 ¡À 1 vs. post©\FO 0 ¡À 1 mmHg, P < 0.05; young £¿30 mmHg: pre©\FO £¿5 ¡À 1 vs. post©\FO £¿5 ¡À 2 mmHg). In conclusion, FO supplementation attenuates the mean BP response but does not affect the renal vasoconstrictor response to orthostatic stress in older adults
%K Aging
%K blood pressure
%K fish oil
%K orthostasis
%K renal vasoconstriction
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5907940/