%0 Journal Article
%T Presynaptic dopaminergic terminal imaging and non-motor symptoms assessment of Parkinson¡¯s disease: evidence for dopaminergic basis?
%A A Sauerbier
%A H Carr
%A K Ray Chaudhuri
%A M Politis
%A MA Qamar
%A P Loehrer
%J Archive of "NPJ Parkinson's Disease".
%D 2017
%R 10.1038/s41531-016-0006-9
%X Parkinson¡¯s disease (PD) is now considered to be a multisystemic disorder consequent on multineuropeptide dysfunction including dopaminergic, serotonergic, cholinergic, and noradrenergic systems. This multipeptide dysfunction leads to expression of a range of non-motor symptoms now known to be integral to the concept of PD and preceding the diagnosis of motor PD. Some non-motor symptoms in PD may have a dopaminergic basis and in this review, we investigate the evidence for this based on imaging techniques using dopamine-based radioligands. To discuss non-motor symptoms we follow the classification as outlined by the validated PD non-motor symptoms scale
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445592/