%0 Journal Article
%T Thalamocortical network activity enables chronic tic detection in humans with Tourette syndrome
%A Aysegul Gunduz
%A Daniel Martinez-Ramirez
%A Enrico Opri
%A Jonathan B. Shute
%A Kelly D. Foote
%A Michael S. Okun
%A P. Justin Rossi
%A Rene Molina
%J Archive of "NeuroImage : Clinical".
%D 2016
%R 10.1016/j.nicl.2016.06.015
%X Tourette syndrome (TS) is a neuropsychiatric disorder characterized by multiple motor and vocal tics. Deep brain stimulation (DBS) is an emerging therapy for severe cases of TS. We studied two patients with TS implanted with bilateral Medtronic Activa PC + S DBS devices, capable of chronic recordings, with depth leads in the thalamic centromedian¨Cparafascicular complex (CM-PF) and subdural strips over the precentral gyrus. Low-frequency (1¨C10 Hz) CM-PF activity was observed during tics, as well as modulations in beta rhythms over the motor cortex. Tics were divided into three categories: long complex, complex, and simple. Long complex tics, tics involving multiple body regions and lasting longer than 5 s, were concurrent with a highly detectable thalamocortical signature (average recall [sensitivity] 88.6%, average precision 96.3%). Complex tics were detected with an average recall of 63.9% and precision of 36.6% and simple tics an average recall of 39.3% and precision of 37.9%. The detections were determined using data from both patients
%K Tourette syndrome
%K Centromedian thalamus
%K Motor cortex
%K Deep brain stimulation
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936504/