%0 Journal Article
%T Real-time fMRI amygdala neurofeedback positive emotional training normalized resting-state functional connectivity in combat veterans with and without PTSD: a connectome-wide investigation
%A Brent E. Wurfel
%A Chung-Ki Wong
%A Frank Krueger
%A Jerzy Bodurka
%A Masaya Misaki
%A Matthew Feldner
%A Raquel Phillips
%A Vadim Zotev
%J Archive of "NeuroImage : Clinical".
%D 2018
%R 10.1016/j.nicl.2018.08.025
%X Self-regulation of brain activation using real-time functional magnetic resonance imaging neurofeedback (rtfMRI-nf) is an emerging approach for treating mood and anxiety disorders. The effect of neurofeedback training on resting-state functional connectivity warrants investigation as changes in spontaneous brain activation could reflect the association between sustained symptom relief and brain alteration. We investigated the effect of amygdala-focused rtfMRI-nf training on resting-state functional connectivity in combat veterans with and without posttraumatic stress disorder (PTSD) who were trained to increase a feedback signal reflecting left amygdala activity while recalling positive autobiographical memories (Zotev et al., 2018). The analysis was performed in three stages: i) first, we investigated the connectivity in the left amygdala region; ii) next, we focused on the abnormal resting-state functional connectivity identified in our previous analysis of this data (Misaki et al., 2018); and iii) finally, we performed a novel data-driven longitudinal connectome-wide analysis. We introduced a longitudinal multivariate distance matrix regression (MDMR) analysis to comprehensively examine neurofeedback training effects beyond those associated with abnormal baseline connectivity
%K combat veterans
%K neurofeedback
%K amygdala
%K positive memories
%K prefrontal cortex
%K precuneus
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6118041/