%0 Journal Article
%T The anatomy of the human medial forebrain bundle: Ventral tegmental area connections to reward-associated subcortical and frontal lobe regions
%A Christoph Kaller
%A Horst Urbach
%A Karl Egger
%A Lena Valerie Schumacher
%A Marco Reisert
%A Peter Christoph Reinacher
%A Thomas Eduard Schlaepfer
%A Volker Arnd Coenen
%J Archive of "NeuroImage : Clinical".
%D 2018
%R 10.1016/j.nicl.2018.03.019
%X Despite their importance in reward, motivation, and learning there is only sparse anatomical knowledge about the human medial forebrain bundle (MFB) and the connectivity of the ventral tegmental area (VTA). A thorough anatomical and microstructural description of the reward related PFC/OFC regions and their connection to the VTA - the superolateral branch of the MFB (slMFB) - is however mandatory to enable an interpretation of distinct therapeutic effects from different interventional treatment modalities in neuropsychiatric disorders (DBS, TMS etc.). This work aims at a normative description of the human MFB (and more detailed the slMFB) anatomy with respect to distant prefrontal connections and microstructural features
%K Brain
%K Deep brain stimulation
%K Depression
%K Human
%K Medial forebrain bundle
%K Normal anatomy
%K Obsessive compulsive disorder
%K TMS
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964495/