%0 Journal Article
%T Large next-generation sequencing gene panels in genetic heart disease: challenges in clinical practice
%A H. Bikker
%A I. Christiaans
%A M. Alders
%A O. R. F. Mook
%A R. H. Lekanne dit Deprez
%J Archive of "Netherlands Heart Journal".
%D 2019
%R 10.1007/s12471-019-1251-4
%X Next-generation sequencing gene panels are increasingly used for genetic diagnosis in inherited cardiac diseases. Besides pathogenic variants, multiple variants, variants of uncertain significance (VUS) and incidental findings can be detected. Such test results can be challenging for counselling and clinical decision making
%K Next-generation sequencing
%K Variants of unknown significance
%K Cardiogenetics
%K Gene panel
%K Counselling
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533326/