%0 Journal Article
%T LSMO Nanoparticles Coated by Hyaluronic Acid for Magnetic Hyperthermia
%A Jiangwei Cao
%A Mai Lu
%A Tao Wang
%A Xi Liu
%A Ying Wang
%A Yuanwei Chen
%J Archive of "Nanoscale Research Letters".
%D 2016
%R 10.1186/s11671-016-1756-3
%X Magnetic hyperthermia with the treating temperature range of 41¨C46 ¡ãC is an alternative therapy for cancer treatment. In this article, lanthanum strontium manganates (La1£¿xSrxMnO3, 0.25£¿¡Ü£¿¡Á£¿¡Ü£¿0.35) magnetic nanoparticles coated by hyaluronic acid (HA) which possesses the ability of targeting tumor cells were prepared by a simple hydrothermal method combined with a high-energy ball milling technique. The crystal structure, morphology, magnetic properties of the HA-coated magnetic nanoparticles (MNPs), and their heating ability under alternating magnetic field were investigated. It was found the HA-coated La0.7Sr0.3MnO3, with particle diameter of ~100 nm, Curie temperature of 45 ¡ãC at a concentration 6 mg/ml, gave the optimal induction heating results. The heating temperature saturates at 45.7 ¡ãC, and the ESAR is 5.7£¿¡Á£¿10£¿3 W/g£¿¡¤£¿kHz£¿¡¤£¿(kA/m2) which is much higher than other reported results
%K LSMO
%K Functionalization
%K Magnetic hyperthermia
%K Hyaluronic acid
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135707/