%0 Journal Article
%T Elaboration of Trans-Resveratrol Derivative-Loaded Superparamagnetic Iron Oxide Nanoparticles for Glioma Treatment
%A Dominique Vervandier-Fasseur
%A Fadoua Sallem
%A G¨¦rard Lizard
%A Julien Boudon
%A Lionel Maurizi
%A Nadine Millot
%A Rihab Haji
%A Thomas Nury
%J Archive of "Nanomaterials".
%D 2019
%R 10.3390/nano9020287
%X In this work, new nanohybrids based on superparamagnetic iron oxide nanoparticles (SPIONs) were elaborated and discussed for the first time as nanovectors of a derivative molecule of trans-resveratrol (RSV), a natural antioxidant molecule, which can be useful for brain disease treatment. The derivative molecule was chemically synthesized (4¡¯-hydroxy-4-(3-aminopropoxy) trans-stilbene: HAPtS) and then grafted onto SPIONs surface using an organosilane coupling agent, which is 3-chloropropyltriethoxysilane (CPTES) and based on nucleophilic substitution reactions. The amount of HAPtS loaded onto SPIONs surface was estimated by thermogravimetric analysis (TGA) and X-ray photoelectron spectroscopy (XPS) analyses at 116 ¦Ìmol¡¤g£¿1 SPIONs. The synthesized HAPtS molecule, as well as the associated nanohybrids, were fully characterized by transmission electron microscopy (TEM), XPS, TGA, infrared (IR) and UV-visible spectroscopies, dynamic light scattering (DLS), and zeta potential measurements. The in vitro biological assessment of the synthesized nanohybrid¡¯s efficiency was carried out on C6 glioma cells and showed that the nanovector SPIONs-CPTES-HAPtS do not affect the mitochondrial metabolism (MTT test), but damage the plasma membrane (FDA test), which could contribute to limiting the proliferation of cancerous cells (clonogenic test) at a HAPtS concentration of 50 ¦ÌM. These nanoparticles have a potential cytotoxic effect that could be used to eliminate cancer cells
%K iron oxide superparamagnetic nanoparticles
%K trans-resveratrol derivative
%K drug delivery
%K glioma
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409721/