%0 Journal Article
%T Non-parametric intravoxel incoherent motion analysis in patients with intracranial lesions: Test-retest reliability and correlation with arterial spin labeling
%A Andreas Boss
%A Cristina Rossi
%A Matthias Guckenberger
%A Moritz C. Wurnig
%A Oliver Riesterer
%A Pinar S. £¿zbay
%A Sonja Stieb
%A Tobias Weiss
%J Archive of "NeuroImage : Clinical".
%D 2016
%R 10.1016/j.nicl.2016.05.022
%X Intravoxel incoherent motion (IVIM) analysis of diffusion imaging data provides biomarkers of true passive water diffusion and perfusion properties. A new IVIM algorithm with variable adjustment of the b-value threshold separating diffusion and perfusion effects was applied for cerebral tissue characterization in healthy volunteers, computation of test-retest reliability, correlation with arterial spin labeling, and assessment of applicability in a small cohort of patients with malignant intracranial masses. The main results of this study are threefold: (i) accounting for regional differences in the separation of the perfusion and the diffusion components improves the reliability of the model parameters; (ii) if differences in the b-value threshold are not accounted for, a significant tissue-dependent systematic bias of the IVIM parameters occurs; (iii) accounting for voxel-wise differences in the b-value threshold improves the correlation with CBF measurements in healthy volunteers and patients. The proposed algorithm provides a robust characterization of regional micro-vascularization and cellularity without a priori assumptions on tissue diffusion properties. The glioblastoma multiforme with its inherently high variability of tumor vascularization and tumor cell density may benefit from a non-invasive clinical characterization of diffusion and perfusion properties
%K Intravoxel incoherent motion
%K IVIM
%K Arterial spin labeling
%K ASL
%K Test-retest reliability
%K Glioblastoma multiforme
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910187/