%0 Journal Article
%T Albumin Submicron Particles with Entrapped Riboflavin¡ªFabrication and Characterization
%A Ausanai Prapan
%A Chiraphat Kloypan
%A Hans B£¿umler
%A Kathrin Smuda
%A Nittiya Suwannasom
%A Nuttakorn Baisaeng
%A Radostina Georgieva
%A Saranya Chaiwaree
%A Waraporn Kaewprayoon
%J Archive of "Nanomaterials".
%D 2019
%R 10.3390/nano9030482
%X Although riboflavin (RF) belongs to the water-soluble vitamins of group B, its solubility is low. Therefore, the application of micro-formulations may help to overcome this limiting factor for the delivery of RF. In this study we immobilized RF in newly developed albumin submicron particles prepared using the Co-precipitation Crosslinking Dissolution technique (CCD-technique) of manganese chloride and sodium carbonate in the presence of human serum albumin (HSA) and RF. The resulting RF containing HSA particles (RF-HSA-MPs) showed a narrow size distribution in the range of 0.9 to 1 ¦Ìm, uniform peanut-like morphology, and a zeta-potential of £¿15 mV. In vitro release studies represented biphasic release profiles of RF in a phosphate buffered saline (PBS) pH 7.4 and a cell culture medium (RPMI) 1640 medium over a prolonged period. Hemolysis, platelet activation, and phagocytosis assays revealed a good hemocompatibility of RF-HSA-MPs
%K riboflavin
%K immobilization
%K biopolymer
%K CCD-technique
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474188/