%0 Journal Article
%T GABAergic Interneurons are Required for Generation of Slow CA1 Oscillation in Rat Hippocampus
%A Lidan Wang
%A Xiaolin Xue
%A Yan Yang
%A Yu-zhang Liu
%A Yuan Xu
%A Zhiru Wang
%J Archive of "Neuroscience Bulletin".
%D 2016
%R 10.1007/s12264-016-0049-2
%X Complete hippocampal formation in vitro and whole-cell recordings from CA1 PCs and FS cells. A Left, image of a completely isolated rat hippocampus (scale bar, 0.3 cm); right, image of the CA1 cell layer (scale bar, 25 ¦̀m; top view). B Representative recordings displaying the low firing rates with adaptation in a pyramidal cell (PC) and sustained firing at high rates in a fast-spiking (FS) cell recorded at depolarizing potentials indicated by arrows. Recordings were performed in the presence of the AMPAR antagonist DNQX (20 ¦̀mol/L). C For the two cells shown in B (before DNQX application), spontaneous membrane-potential changes and firing of the PC (left) and FS cell (right; inset, high temporal resolution of the fast afterhyperpolarization after the end of action potentials). Resting potentials are indicated on the left of each trace; action potentials were partially truncated
%K Hippocampus
%K Oscillation
%K Synchronization
%K GABAergic interneuron
%K GABAA receptor
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563788/