%0 Journal Article
%T Quantitative measures of walking and strength provide insight into brain corticospinal tract pathology in multiple sclerosis
%A Jennifer Keller
%A Kathleen M Zackowski
%A Nora E Fritz
%A Peter A Calabresi
%J Archive of "NeuroImage : Clinical".
%D 2017
%R 10.1016/j.nicl.2017.02.006
%X At least 85% of individuals with multiple sclerosis report walking dysfunction as their primary complaint. Walking and strength measures are common clinical measures to mark increasing disability or improvement with rehabilitation. Previous studies have shown an association between strength or walking ability and spinal cord MRI measures, and strength measures with brainstem corticospinal tract magnetization transfer ratio. However, the relationship between walking performance and brain corticospinal tract magnetization transfer imaging measures and the contribution of clinical measurements of walking and strength to the underlying integrity of the corticospinal tract has not been explored in multiple sclerosis. The objectives of this study were explore the relationship of quantitative measures of walking and strength to whole-brain corticospinal tract-specific MRI measures and to determine the contribution of quantitative measures of function in addition to basic clinical measures (age, gender, symptom duration and Expanded Disability Status Scale) to structural imaging measures of the corticospinal tract. We hypothesized that quantitative walking and strength measures would be related to brain corticospinal tract-specific measures, and would provide insight into the heterogeneity of brain pathology
%K Multiple sclerosis
%K Magnetization transfer imaging
%K Diffusion tensor imaging
%K Walking
%K Strength
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338912/