%0 Journal Article
%T Association study of the excitatory amino acid transporter 2 (EAAT2) and glycine transporter 1 (GlyT1) gene polymorphism with schizophrenia in a Polish population
%A Aleksander Owczarek
%A Jan Kowalski
%A Krzysztof Kucia
%A Ma£żgorzata Kowalczyk
%A Tomasz M£żdrala
%A Wojciech Merk
%J Archive of "Neuropsychiatric Disease and Treatment".
%D 2019
%R 10.2147/NDT.S194924
%X Background: Excitatory amino acid transporter 2 encoded by SLC1A2 is responsible for approximately 90% of glutamate uptake. Glycine transporter 1, encoded by SLC6A9, is responsible for maintaining a low concentration of the N-methyl-D-aspartate receptor (NMDAR) co-agonist ¨C glycine in the synaptic cleft, suggesting its participation in the development of the NMDARs hypofunction described in schizophrenia. Aim: The aim of this study was to evaluate whether the functional polymorphism-181 A/C (rs4354668) of the SLC1A2 and the rs2486001 (IVS3+411 G/A) in the SLC6A9 are involved in schizophrenia development and its clinical picture in the Polish population
%K schizophrenia
%K glutamate system
%K excitatory amino acid transporter 2
%K glycine transporter 1
%K polymorphism
%K PANSS
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499478/