%0 Journal Article
%T Photo-Magnetic Irradiation-Mediated Multimodal Therapy of Neuroblastoma Cells Using a Cluster of Multifunctional Nanostructures
%A David Diercks
%A Gamage Tharaka
%A Jian Peng
%A Rahul Atmaramani
%A Rohini Atluri
%A Santaneel Ghosh
%A Somesree GhoshMitra
%A Thomas McCallister
%J Archive of "Nanomaterials".
%D 2018
%R 10.3390/nano8100774
%X The use of high intensity chemo-radiotherapies has demonstrated only modest improvement in the treatment of high-risk neuroblastomas. Moreover, undesirable drug specific and radiation therapy-incurred side effects enhance the risk of developing into a second cancer at a later stage. In this study, a safer and alternative multimodal therapeutic strategy involving simultaneous optical and oscillating (AC, Alternating Current) magnetic field stimulation of a multifunctional nanocarrier system has successfully been implemented to guide neuroblastoma cell destruction. This novel technique permitted the use of low-intensity photo-magnetic irradiation and reduced the required nanoparticle dose level. The combination of released cisplatin from the nanodrug reservoirs and photo-magnetic coupled hyperthermia mediated cytotoxicity led to the complete ablation of the B35 neuroblastoma cells in culture. Our study suggests that smart nanostructure-based photo-magnetic hybrid irradiation is a viable approach to remotely guide neuroblastoma cell destruction, which may be adopted in clinical management post modification to treat aggressive cancers
%K photo-magnetic actuation
%K cisplatin
%K nanoparticle
%K MYCN
%K multimodal therapy
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215308/