%0 Journal Article
%T Implantable hyaluronic acid-deferoxamine conjugate prevents nonunions through stimulation of neovascularization
%A Alexis Donneys
%A Alicia Snider
%A Kavitha Ranganathan
%A Marcus Laird Forrest
%A Mark S. Cohen
%A Noah S. Nelson
%A Qiuhong Yang
%A Russell Ettinger
%A Sagar S. Deshpande
%A Steven R. Buchman
%A Ti Zhang
%J Archive of "NPJ Regenerative Medicine".
%D 2019
%R 10.1038/s41536-019-0072-9
%X Development of implantable HA-DFO. a HA-DFO general chemical structure. b 1H-NMR spectra (D2O, 400£¿MHz) of HA (752£¿kDa)-DFO-MA and HA (752£¿kDa)-DFO confirming the characteristic peaks of MA (6.5¨C5.5£¿ppm), HA (4.0¨C3.0£¿ppm) and DFO (2.0¨C1.0£¿ppm), highlighted from left to right, respectively. The peak at ¦Ä£¿=£¿4.70 in each spectrum corresponds to the solvent residue. c HA (752£¿kDa)-DFO-MA hydrogel before and after overnight incubation with iron. Note the rust color indicating successful iron chelation within the Hydrogel-Iron (III) complex. Scale bar length£¿=£¿5£¿mm. d Percent molecular weight of unmodified HA (752£¿kDa), and its two derivatives in response to hyaluronidase enzymatic degradatio
%K Fracture repair
%K Regenerative medicine
%K Translational research
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529413/