%0 Journal Article
%T SERS-Based Flavonoid Detection Using Ethylenediamine-¦Â-Cyclodextrin as a Capturing Ligand
%A Bong-Hyun Jun
%A Dae Hong Jeong
%A Daham Jeong
%A Eunae Cho
%A Eunil Hahm
%A Hyun Jong Chung
%A Jae Min Choi
%A Jae-Hyuk Yu
%A Jaehi Kim
%A Kyeonghui Park
%A Seunho Jung
%A Sung Ho Jhang
%A Won-Yeop Rho
%A Yoon-Sik Lee
%J Archive of "Nanomaterials".
%D 2017
%R 10.3390/nano7010008
%X Ethylenediamine-modified ¦Â-cyclodextrin (Et-¦Â-CD) was immobilized on aggregated silver nanoparticle (NP)-embedded silica NPs (SiO2@Ag@Et-¦Â-CD NPs) for the effective detection of flavonoids. Silica NPs were used as the template for embedding silver NPs to create hot spots and enhance surface-enhanced Raman scattering (SERS) signals. Et-¦Â-CD was immobilized on Ag NPs to capture flavonoids via host-guest inclusion complex formation, as indicated by enhanced ultraviolet absorption spectra. The resulting SiO2@Ag@Et-¦Â-CD NPs were used as the SERS substrate for detecting flavonoids, such as hesperetin, naringenin, quercetin, and luteolin. In particular, luteolin was detected more strongly in the linear range 10£¿7 to 10£¿3 M than various organic molecules, namely ethylene glycol, ¦Â-estradiol, isopropyl alcohol, naphthalene, and toluene. In addition, the SERS signal for luteolin captured by the SiO2@Ag@Et-¦Â-CD NPs remained even after repeated washing. These results indicated that the SiO2@Ag@Et-¦Â-CD NPs can be used as a rapid, sensitive, and selective sensor for flavonoids
%K cyclodextrin
%K ethylenediamine cyclodextrin
%K surface-enhanced Raman scattering (SERS)
%K flavonoids
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295198/