%0 Journal Article
%T Astrocyte dysfunction following molybdenum-associated purine loading could initiate Parkinson¡¯s disease with dementia
%A Christopher A. Bourke
%J Archive of "NPJ Parkinson's Disease".
%D 2018
%R 10.1038/s41531-018-0045-5
%X Purine catabolism in humans and sheep. XOD is the molybdenum-dependant enzyme xanthine oxidase-dehydrogenase. Molybdenum sufficiency produces a different outcome to molybdenum deficiency. Outcome for Mo-sufficient humans and sheep: (1) Xanthine oxidase-dehydrogenase activity is high. (2) Dietary purines are catabolised in the gut and liver and excreted. (3) They cannot be ¡°salvaged¡± hence they do not reach the CNS. Outcome for Mo-deficient humans and sheep: (1) Xanthine oxidase-dehydrogenase activity is very low. (2) Dietary purines are not catabolised hence reach the general circulation. (3) Some are ¡°salvaged¡± and reach the CNS the rest are excreted uncatabolise
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861100/