%0 Journal Article
%T Integrating ¡®Omics¡¯ Approaches to Prioritize New Pathogenetic Mechanisms for Mental Disorders
%A Annamaria Cattaneo
%A Carmine M Pariante
%J Archive of "Neuropsychopharmacology".
%D 2018
%R 10.1038/npp.2017.221
%X Neuropsychopharmacology research is between a rock and a hard place. The rock is the historical, but slow, hypothesis-driven approach, where discovery occurs by testing candidate mechanisms in already well-known biological models. The hard place is the innovative, but overwhelming, hypothesis-free approach, where ¡®omics¡¯ analyses of everything that is analyzable generates a deluge of data implicating hitherto unknown mechanisms. So, either we have little data on things we already know, or too much data and cannot find the needle in a haystack. One solution is to mix apples and oranges: integrating cross-species and cross-tissues ¡®omics¡¯ data to find mechanisms that recur across different experimental and clinical models. The idea has been used with remarkable success. And yes, we will finish with the proverbs now
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719117/