%0 Journal Article
%T The role of Galectin-3 in modulating tumor growth and immunosuppression within the tumor microenvironment
%A Annah S. Rolig
%A Mohammad Farhad
%A William L. Redmond
%J Archive of "Oncoimmunology".
%D 2018
%R 10.1080/2162402X.2018.1434467
%X The efficacy of cancer immunotherapy is limited, in part, by the multitude of immunosuppressive mechanisms present within the tumor microenvironment (TME). Galectin-3 (Gal-3) is a lectin that contributes to TME immunosuppression and regulates diverse functions including cellular homeostasis and cancer biology. Increased Gal-3 expression during cancer progression augments tumor growth, invasiveness, metastatic potential, and immune suppression, which highlights the potential use of Gal-3 as a therapeutic target capable of modulating anti-tumor immunity. Here, we discuss the mechanisms by which Gal-3 regulates lymphocytes, the role of Gal-3 in lung and prostate tumors, and the contribution of Gal-3 to TME immunosuppression
%K galectin-3
%K immunosuppression
%K immunotherapy
%K lectin
%K tumor immunology
%K tumor microenvironment
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980349/