%0 Journal Article
%T Effect of PolyGlycopleX (PGX) Consumption on Blood Lipid Profiles in Healthy, Low CVD Risk Overweight Adults
%A Anthony P. James
%A Deasy Irawati
%A Deborah A. Kerr
%A Haelee K. Fenton
%A Roland J. Gahler
%A Simon Wood
%A Stuart K. Johnson
%A Vicky A. Solah
%A Wendy Hunt
%A Xingqiong Meng
%J Archive of "Nutrients".
%D 2019
%R 10.3390/nu11040717
%X Raised blood lipid levels are associated with a risk of a cardiovascular disease (CVD). Moderate reductions in several CVD factors such as total, low-density lipoprotein (LDL) cholesterol and non-high-density lipoprotein (non-HDL) cholesterol concentrations may be more effective in reducing overall risk than a major reduction in just one. A blind, randomised controlled trial was conducted with 120 healthy overweight (BMI 25¨C30) adults aged 25¨C70 years who were non-smokers, not diabetic and of low risk of cardiovascular disease, as assessed by the Framingham risk equation. Participants consumed 4.5 g PolyGlycopleX (PGX) as softgel capsules (PGXS) or 5 g PGX granules (PGXG) or 5 g rice flour (RF) with meals three times a day for 12 weeks. Total, LDL and non-HDL cholesterol were all significantly reduced (£¿6%, £¿5% and £¿3.5%, respectively) post the PGX granule treatment; however, PGX in softgel capsule form did not affect blood lipid profiles. Daily consumption of PGX granules in overweight low CVD risk adults produced lipid changes indicating a CVD preventative benefit
%K blood lipids
%K cardiovascular
%K disease risk
%K cholesterol
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520870/