%0 Journal Article
%T Protective effects against tumors and infection by interleukin-27 through promotion of expansion and differentiation of hematopoietic stem cells into myeloid progenitors
%A Hideaki Hasegawa
%A Izuru Mizoguchi
%A Mingli Xu
%A Mio Ohashi
%A Nakaba Ochiai
%A Naoko Orii
%A Takayuki Yoshimoto
%A Taro Nagai
%A Toshiyuki Owaki
%A Yuki Mochizuki
%A Yukino Chiba
%J Archive of "Oncoimmunology".
%D 2018
%R 10.1080/2162402X.2017.1421892
%X Interleukin (IL)-27 is a multifunctional cytokine that belongs to the IL-6/IL-12 family and has potent antitumor activity through various mechanisms. Our novel findings indicate that IL-27 directly acts on hematopoietic stem cells and promotes their expansion and differentiation into myeloid progenitors to control infection and to eradicate tumors
%K IL-27
%K hematopoietic stem cells
%K myeloid progenitors
%K emergency myelopoiesis
%K antitumor activity
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927478/