%0 Journal Article
%T Immunohistochemical Expression of TGF-¦¢1, SMAD4, SMAD7, TGF¦ÂRII and CD68-Positive TAM Densities in Papillary Thyroid Cancer
%A Irena Manolova
%A Koni Ivanova
%A Maria-Magdalena Ignatova
%A Maya Gulubova
%J Archive of "Open Access Macedonian Journal of Medical Sciences".
%D 2018
%R 10.3889/oamjms.2018.105
%X Papillary thyroid carcinoma (PTC) accounts for 80% of the thyroid malignancies that are characterised by slow growth and an excellent prognosis. Over-expression of SMAD4 protein restores TGF-¦Â signalling, determines a strong increase in anti-proliferative effect and reduces invasive potential of tumour cells expressing it
%K Thyroid cancer
%K TGF-¦Â pathway
%K Immunohistochemical expression
%K Macrophages
%K Tumorigenesis
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874362/