%0 Journal Article
%T Systemic activation of antigen-presenting cells via RNA-loaded nanoparticles
%A Adam Grippin
%A Catherine Flores
%A Christina Pham
%A Duane A. Mitchell
%A Elias J. Sayour
%A Gabriel De Leon
%A Hanna Kemeny
%A Jianping Huang
%A John H. Sampson
%A Joshua Chua
%A Luis Sanchez-Perez
%J Archive of "Oncoimmunology".
%D 2017
%R 10.1080/2162402X.2016.1256527
%X While RNA-pulsed dendritic cell (DC) vaccines have shown promise, the advancement of cellular therapeutics is fraught with developmental challenges. To circumvent the challenges of cellular immunotherapeutics, we developed clinically translatable nanoliposomes that can be combined with tumor-derived RNA to generate personalized tumor RNA-nanoparticles (NPs) with considerable scale-up capacity. RNA-NPs bypass MHC restriction, are amenable to central distribution, and can provide near immediate immune induction
%K Cancer immunotherapy
%K cancer vaccines
%K dendritic cells
%K liposomes
%K RNA nanoparticles
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5283636/