%0 Journal Article
%T Enhancing the clinical coverage and anticancer efficacy of immune checkpoint blockade through manipulation of the gut microbiota
%A Ivo Gomperts Boneca
%A Jonathan M. Pitt
%A Laurence Zitvogel
%A Marie V¨¦tizou
%A Mathias Chamaillard
%A Patricia Lepage
%J Archive of "Oncoimmunology".
%D 2017
%R 10.1080/2162402X.2015.1132137
%X Although anticancer therapy with immune checkpoint blockers has seen unprecedented success, it fails to control neoplasia in most patients and often causes immune-related adverse events (irAEs). Our recent research shows the immunostimulatory and antitumor effects of CTLA-4 blockade depend on distinct Bacteroides species of the gut microbiota, signifying novel approaches to improve such immunotherapies
%K Anti-CTLA-4
%K Bacteroides
%K cancer
%K ipilimumab
%K microbiota
%K microbiome
%K T cell
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5283646/