%0 Journal Article
%T POLE proofreading mutation, immune response and prognosis in endometrial cancer
%A David N. Church
%A Inge C. van Gool
%A Tjalling Bosse
%J Archive of "Oncoimmunology".
%D 2016
%R 10.1080/2162402X.2015.1072675
%X Endometrial cancers (ECs) with POLE proofreading mutations are typified by ultramutation and excellent prognosis. We investigated whether these were related, and found that POLE-mutant ECs display a robust T cell response that corresponds to an enrichment of antigenic tumor neopeptides. Enhanced immunogenicity may explain the favorable outcome of POLE-mutant ECs
%K DNA polymerase ŠĆ
%K POLE
%K ultramutation
%K neopeptide
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839358/