%0 Journal Article %T Responsiveness of hypothalamo-pituitary-adrenal axis to leptin is impaired in diet-induced obese rats %A Andrew C. Shin %A Andrew Woolcock %A Katrina Linning %A Madhu P. Sirivelu %A Michelle James %A Priya Balasubramanian %A Puliyur S. MohanKumar %A Sheba M. J. MohanKumar %J Archive of "Nutrition & Diabetes". %D 2019 %R 10.1038/s41387-019-0076-y %X a, b Note the marked reduction in PVN NE levels in both DIO and DR rats, indicating normal responsiveness to exogenous leptin. c, d Decrease in ME CRH or serum corticosterone in DR rats following leptin injection is not observed in DIO rats. Bars with different notations are significantly different from each other (p£¿<£¿0.05). * indicates significant difference from the rest of the groups (p£¿<£¿0.05). 6¨C8 rats/grou %U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423225/