%0 Journal Article %T The Effect of Mesenchymal Stem Cell Wharton¡¯s Jelly on Matrix Metalloproteinase-1 and Interleukin-4 Levels in Osteoarthritis Rat Model %A Endrinaldi Endrinaldi %A Eryati Darwin %A Gusti Revilla %A Nasrul Zubir %J Archive of "Open Access Macedonian Journal of Medical Sciences". %D 2019 %R 10.3889/oamjms.2019.152 %X Osteoarthritis (OA) is generally considered a degenerative joint disease caused by biomechanical changes and the ageing process. In OA pathogenesis, the development of OA is thought to be regulated largely by excess matrix metalloproteinase (MMP), which contributes to the degradation of extracellular matrices such as MMP-1 and Interleukin-4 %K Matrix Metalloproteinase-1 %K Mesenchymal Stem Cell Wharton Jelly %K Interleukin-4 %K Osteoarthritis %U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420948/