%0 Journal Article
%T Transforming Growth Factor Beta 1 Regulates Fibroblast Growth Factor 7 Expression in Schwann Cells
%A Doan Nguyen
%A Olawale A. R. Sulaiman
%J Archive of "The Ochsner Journal".
%D 2019
%R 10.31486/toj.18.0106
%X Background: Our previous work demonstrated that application of transforming growth factor beta 1 (TGF-¦Â1) and forskolin to the repair site after chronic denervation and axotomy has a mitogenic effect, reactivates Schwann cells (SCs), and supports axonal regeneration. We found decreased expression of fibroblast growth factor 7 (FGF-7), a factor involved in synaptic organization and maintenance. Using an in vitro system, we examined the molecular mechanism of TGF-¦Â1 and forskolin on the regulation of FGF-7 expression in SCs
%K Fibroblast growth factor 7
%K nerve injury
%K nerve regeneration
%K Schwann cells
%K transforming growth factor beta 1
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447212/