%0 Journal Article
%T Chelerythrine induced cell death through ROS-dependent ER stress in human prostate cancer cells
%A Feiping Li
%A Guanfu Wang
%A Haiping Li
%A Hongyuan Yu
%A Lifu Huang
%A Songjiang Wu
%A Yanying Yang
%A Zihua Han
%J Archive of "OncoTargets and therapy".
%D 2018
%R 10.2147/OTT.S157707
%X Prostate cancer is the most common noncutaneous cancer and the second leading cause of cancer-related mortality worldwide and the third in USA in 2017. Chelerythrine (CHE), a naturalbenzo[c]phenanthridine alkaloid, formerly identified as a protein kinase C inhibitor, has also shown anticancer effect through a number of mechanisms. Herein, effect and mechanism of the CHE-induced apoptosis via reactive oxygen species (ROS)-mediated endoplasmic reticulum (ER) stress in prostate cancer cells were studied for the first time
%K chelerythrine
%K reactive oxygen species
%K endoplasmic reticulum stress
%K apoptosis
%K prostate cancer
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951218/