%0 Journal Article
%T Effects of Hazelnut Consumption on Blood Lipids and Body Weight: A Systematic Review and Bayesian Meta-Analysis
%A Antonio Isu
%A Attilio Giacosa
%A Chiara Bologna
%A Davide Guido
%A Gianluca Bonitta
%A Mariangela Rondanelli
%A Simone Perna
%J Archive of "Nutrients".
%D 2016
%R 10.3390/nu8120747
%X Hazelnuts are rich in monounsaturated fatty acids and antioxidant bioactive substances: their consumption has been associated with a decreased risk of cardiovascular disease events. A systematic review and a meta-analysis was performed to combine the results from several trials and to estimate the pooled (overall) effect of hazelnuts on blood lipids and body weight outcomes. Specifically, a Bayesian random effect meta-analysis of mean differences of ¦¤-changes from baseline across treatment (MD¦¤) (i.e., hazelnut-enriched diet vs. control diet) has been conducted. Nine studies representing 425 participants were included in the analysis. The intervention diet lasted 28¨C84 days with a dosage of hazelnuts ranging from 29 to 69 g/day. Out of nine studies, three randomized studies have been meta-analyzed showing a significant reduction in low-density lipoprotein (LDL) cholesterol (pooled MD¦¤ = £¿0.150 mmol/L; 95% highest posterior density interval (95%HPD) = £¿0.308; £¿0.003) in favor of a hazelnut-enriched diet. Total cholesterol showed a marked trend toward a decrease (pooled MD¦¤ = £¿0.127 mmol/L; 95%HPD = £¿0.284; 0.014) and high-density lipoprotein (HDL) cholesterol remained substantially stable (pooled MD¦¤ = 0.002 mmol/L; 95%HPD = £¿0.140; 0.147). No effects on triglycerides (pooled MD¦¤ = 0.045 mmol/L; 95%HPD = £¿0.195; 0.269) and body mass index (BMI) (pooled MD¦¤ = 0.062 kg/m2; 95%HPD = £¿0.293; 0.469) were found. Hazelnut-enriched diet is associated with a decrease of LDL and total cholesterol, while HDL cholesterol, triglycerides and BMI remain substantially unchanged
%K hazelnut
%K lipid
%K cholesterol
%K triglyceride
%K obesity
%K body weight
%K BMI
%K Corylus avellana
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5188407/