%0 Journal Article
%T Intake of Polydextrose Alters Hematology and the Profile of Short Chain Fatty Acids in Partially Gastrectomized Rats
%A Adriana Concei£żon Guercio
%A Alinne Pereira de Castro
%A Anderson Fernandes
%A Camila Fontoura Acosta Ribeiro
%A Cristiano Marcelo Espinola Carvalho
%A Daiana Novello
%A Deiler Sampaio Costa
%A Elisvania Freitas dos Santos
%A Jaime Amaya-Farfan
%A Karine de C¨˘ssia Freitas Gielow
%A Leandro Fontoura Cavalheiro
%A Mariane Moreira Ramiro do Carmo
%A Priscila Aiko Hiane
%A Priscila Neder Morato
%A Ulana Chaves Sarmento
%A Valfredo de Almeida Santos-Junior
%A Valter Arag£żo do Nascimento
%A Wander Fernando de Oliveira Fili¨²
%J Archive of "Nutrients".
%D 2018
%R 10.3390/nu10060792
%X Polydextrose (PDX) ingestion may increase the intestinal absorption of iron. This study evaluated the effects of 7.5% polydextrose supplementation on markers of iron uptake, transport and storage in partially gastrectomized rats. Half of a batch of 40 male Wistar rats (250 g) underwent Billroth II partial gastrectomy with anterior truncal vagotomy (GXT), while the other half underwent sham gastrectomy (SHAM). At 7 postoperative days, the animals were subdivided into four groups (n = 10): Sham Control and GXT Control (no polydextrose); Sham PDX and GXT PDX (with 7.5% PDX). The animals were euthanized after 60 day of PDX treatment. Organ weight, cecal pH, the characterization and quantification of short-chain fatty acids (SCFA), hematological parameters, hepatic iron content and the expression of ferroportin (FPT) in the jejunum, cecum, colon and liver were evaluated. PDX caused changes in the cecum of the supplemented animals, where there was a decrease in pH, increase in cecal wall and marked production of SCFA, especially acetic and propionic acids (p < 0.05). Hepatic iron levels were lower in GXT animals. PDX increased hemoglobin (HGB) values by 29.2% and hematocrit (HCT) by 55.8% in the GXT PDX group compared to the GXT Control group. The GXT PDX group had lower hepatic FPT expression (p < 0.05). PDX led to increased SCFA concentration in the supplemented animals. Considering that SCFAs play a central role in the increasing nutrients uptake, this mechanism may be involved in altering the hematology profile observed in these animals but not enough to reverse iron deficiency anemia in post-gastrectomy rats
%K iron-deficiency anemia
%K gastrectomy
%K prebiotics
%K rats
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024616/