%0 Journal Article
%T The Effect of Increasing the Protein Content of Human Milk Fortifier to 1.8 g/100 mL on Growth in Preterm Infants: A Randomised Controlled Trial
%A Andrew J. McPhee
%A Carmel T. Collins
%A Jacqueline Miller
%A Jessica Reid
%A Maria Makrides
%A Michael J. Stark
%J Archive of "Nutrients".
%D 2018
%R 10.3390/nu10050634
%X The aim of this study was to assess the effect of feeding high protein human milk fortifier (HMF) on growth in preterm infants. In this single-centre randomised trial, 60 infants born 28¨C32 weeks¡¯ gestation were randomised to receive a higher protein HMF providing 1.8 g protein (n = 31) or standard HMF providing 1 g protein per 100 mL expressed breast milk (EBM) (n = 29). The primary outcome was rate of weight gain. Baseline characteristics were similar between groups. There was no difference between high and standard HMF groups for weight gain (mean difference (MD) £¿14 g/week; 95% CI £¿32, 4; p = 0.12), length gain (MD £¿0.01 cm/week; 95% CI £¿0.06, 0.03; p = 0.45) or head circumference gain (MD 0.007 cm/week; 95% CI £¿0.05, 0.06; p = 0.79), despite achieving a 0.7 g/kg/day increase in protein intake in the high protein group. Infants in the high protein group had a higher proportion of lean body mass at trial entry; however, there was no group by time effect on lean mass gains over the study. Increasing HMF protein content to 1.8 g per 100 mL EBM does not improve growth in preterm infants born 28¨C32 weeks¡¯ gestation
%K human milk
%K growth
%K low birth weight
%K human milk fortifier
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986513/