%0 Journal Article %T Descemet's membrane macroperforation during interface irrigation in big bubble deep anterior lamellar keratoplasty %A Mohammed Ziaei %A Susan E. Ormonde %J Archive of "Oman Journal of Ophthalmology". %D 2017 %R 10.4103/ojo.OJO_66_2016 %X This report describes the macroperforation of descemet's membrane (DM) during irrigation of the interface following successful removal of stromal tissue in big bubble (BB) deep anterior lamellar keratoplasty (DALK). A 42-year-old woman with keratoconus underwent a BB DALK procedure. After successful formation of Type 2 bubble and removal of stromal tissue, interface irrigation was performed to remove residual viscoelastic. This led to a macroperforation of DM, and the case was converted to penetrating keratoplasty. To the best of our knowledge, this is the first report of such a complication in the literature. Recognition of a 2 bubble formation during pneumodissection should alert the surgeon to a high risk of DM rupture. We advise against the removal of DM from the donor in such cases as an added measure of safety %K Big bubble %K deep anterior lamellar keratoplasty %K descemet's membrane perforation %K penetrating keratoplasty %U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5657172/