%0 Journal Article
%T Highly efficient IL-21 and feeder cell-driven ex vivo expansion of human NK cells with therapeutic activity in a xenograft mouse model of melanoma
%A Adelheid Cerwenka
%A Ana Stojanovic
%A Markus Granzin
%A Matthias Miller
%A Richard Childs
%A Volker Huppert
%J Archive of "Oncoimmunology".
%D 2016
%R 10.1080/2162402X.2016.1219007
%X Natural killer (NK) cells are promising antitumor effector cells, but the generation of sufficient NK cell numbers for adoptive immunotherapy remains challenging. Therefore, we developed a method for highly efficient ex vivo expansion of human NK cells
%K Cancer immunotherapy
%K EBV-LCL
%K Interleukin-21
%K melanoma
%K Natural killer cells
%K NK cell expansion
%K xenograft mouse model
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048763/