%0 Journal Article
%T Anti-CD73 immunotherapy: A viable way to reprogram the tumor microenvironment
%A Corrado Blandizzi
%A Davide Ferrari
%A Fabio Malavasi
%A Gy£¿rgy Hask¨®
%A Luca Antonioli
%J Archive of "Oncoimmunology".
%D 2016
%R 10.1080/2162402X.2016.1216292
%X The ecto-5'-nucleotidase/CD73 enzyme plays a pivotal role in generating an adenosine-enriched immunosuppressed and pro-angiogenic niche supporting cancer development. The targeting of CD73 leads to reorganization of tumor microenvironment, shaping the phenotype of the infiltrating T cells. The development of CD73 monoclonal antibodies offers a promising new avenue for antineoplastic treatment
%K CD73
%K monoclonal antibody
%K tumor microenvironment
%K immunotherapy
%K autophagy
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048762/