%0 Journal Article
%T Blockade of LAG3 enhances responses of tumor-infiltrating T cells in mismatch repair-proficient liver metastases of colorectal cancer
%A Adriaan A. van Beek
%A Alexandra Brandt
%A Anand G. Menon
%A Boris Galjart
%A Cornelis Verhoef
%A Dave Sprengers
%A Dirk Gr¨šnhagen
%A Guoying Zhou
%A Jaap Kwekkeboom
%A Johan F. Lange
%A Lisanne Noordam
%A Marco J. Bruno
%A Michail Doukas
%A Patrick P. C. Boor
%A Pim J. W. A. Burger
%A Remco Erkens
%A Shanta Mancham
%J Archive of "Oncoimmunology".
%D 2018
%R 10.1080/2162402X.2018.1448332
%X Purpose: Liver metastasis develops in >50% of patients with colorectal cancer (CRC), and is a leading cause of CRC-related mortality. We aimed to identify which inhibitory immune checkpoint pathways can be targeted to enhance functionality of intra-tumoral T-cells in mismatch repair-proficient liver metastases of colorectal cancer (LM-CRC)
%K immunotherapy
%K immune checkpoint inhibitor
%K tumor-infiltrating lymphocyte
%K liver metastasis
%K colorectal cancer
%K peritoneal metastasis
%K LAG3
%K PD-1
%K T cell
%K mismatch repair
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993483/