%0 Journal Article
%T Endurance Exercise Increases Intestinal Uptake of the Peanut Allergen Ara h 6 after Peanut Consumption in Humans
%A Harry J. Wichers
%A Jaap Keijer
%A Kaatje Lenaerts
%A Klaske van Norren
%A Lonneke M. JanssenDuijghuijsen
%A Renger F. Witkamp
%A Sander Grefte
%A Stef J. Koppelman
%J Archive of "Nutrients".
%D 2017
%R 10.3390/nu9010084
%X Controlled studies on the effect of exercise on intestinal uptake of protein are scarce and underlying mechanisms largely unclear. We studied the uptake of the major allergen Ara h 6 following peanut consumption in an exercise model and compared this with changes in markers of intestinal permeability and integrity. Ten overnight-fasted healthy non-allergic men (n = 4) and women (n = 6) (23 ¡À 4 years) ingested 100 g of peanuts together with a lactulose/rhamnose (L/R) solution, followed by rest or by 60 min cycling at 70% of their maximal workload. Significantly higher, though variable, levels of Ara h 6 in serum were found during exercise compared to rest (Peak p = 0.03; area under the curve p = 0.006), with individual fold changes ranging from no increase to an increase of over 150-fold in the uptake of Ara h 6. Similarly, uptake of lactulose (2¨C18 fold change, p = 0.0009) and L/R ratios (0.4¨C7.9 fold change, p = 0.04) were significantly increased which indicates an increase in intestinal permeability. Intestinal permeability and uptake of Ara h 6 were strongly correlated (r = 0.77, p < 0.0001 for lactulose and Ara h 6). Endurance exercise after consumption may lead to increased paracellular intestinal uptake of food proteins
%K intestinal permeability
%K Ara h 6
%K allergen
%K endurance exercise
%K food-dependent exercise-induced anaphylaxis
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295128/