%0 Journal Article
%T Cytokine Induced Killer cells are effective against sarcoma cancer stem cells spared by chemotherapy and target therapy.
%A Alberto Pisacane
%A Anna Sapino
%A Chiara Salfi
%A Dario Sangiolo
%A Erika Fiorino
%A Federica Capozzi
%A Giovanni Grignani
%A Giulia Mesiano
%A Lidia Giraudo
%A Lorenzo DˇŻAmbrosio
%A Loretta Gammaitoni
%A Marco Basiric¨®
%A Massimo Aglietta
%A Ramona Rotolo
%A Sara Butera
%A Valeria Leuci
%A Ymera Pignochino
%J Archive of "Oncoimmunology".
%D 2018
%R 10.1080/2162402X.2018.1465161
%X Metastatic bone and soft tissue sarcomas often relapse after chemotherapy (CHT) and molecular targeted therapy (mTT), maintaining a severe prognosis. A subset of sarcoma cancer stem cells (sCSC) is hypothesized to resist conventional drugs and sustain disease relapses. We investigated the immunotherapy activity of cytokine induced killer cells (CIK) against autologous sCSC that survived CHT and mTT. The experimental platform included two aggressive bone and soft tissue sarcoma models: osteosarcoma (OS) and undifferentiated-pleomorphic sarcoma (UPS)
%K CIK cells
%K sarcomas
%K Cancer stem cells
%K adoptive immunotherapy
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208452/