%0 Journal Article
%T Intramuscular vaccination targeting mucosal tumor draining lymph node enhances integrins-mediated CD8+ T cell infiltration to control mucosal tumor growth
%A Andrew Yang
%A Chien-Fu Hung
%A Emily Farmer
%A Jin Qiu
%A Liping Han
%A Max A. Cheng
%A Shiwen Peng
%A T.-C. Wu
%A Ying Ma
%J Archive of "Oncoimmunology".
%D 2018
%R 10.1080/2162402X.2018.1463946
%X Purpose: Mucosal immunization is suggested to be crucial for controlling tumors in the mucosal region; however, therapeutic DNA vaccination with electroporation in various mucosal sites has yet to become clinically adaptable. Since tumor-draining lymph nodes (tdLNs) have been suggested as immune-educated sites that can be utilized to mount a potent antitumor immune response, we examined whether intramuscular DNA vaccination with electroporation at sites that target the mucosal tdLNs could elicit mucosal immune response to restrict tumor growth
%K Immunotherapy
%K Mucosal immunity
%K Tumor draining lymph node
%K LPAM-1
%K CD49a
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136882/