%0 Journal Article
%T Dermatofibrosarcoma Protuberans: Retrospective Single Center Analysis Over 16 Years
%A Dana Langner
%A Georgi Tchernev
%A Jacqueline Sch£¿nlebe
%A Katlein Fran£¿a
%A Torello Lotti
%A Uwe Wollina
%J Archive of "Open Access Macedonian Journal of Medical Sciences".
%D 2018
%R 10.3889/oamjms.2018.030
%X Dermatofibrosarcoma protuberans (DFSP) is rare mesenchymal neoplasia with a high risk of local recurrence but a low risk of metastatic spread. Tumor cells express CD34 and show a characteristic translocation t(17;22)(q22;q13). We analysed the documented cases at the Department of Dermatology and Allergology between 08/2001 and 08/2017. The diagnosis had been confirmed by histology and immunohistology in all cases. We identified four adults and a pediatric patient with DFSP. All patients were treated by wide surgical excision and controlled by three-dimensional histologic margin control. We observed no recurrence and no metastatic spread. We discuss prognostic factors and emerging treatments
%K Sarcoma
%K dermatofibrosarcoma protuberans
%K CD34
%K surgery
%K outcome
%K targeted therapy
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816309/