%0 Journal Article
%T The Relationship between Dietary Vitamin K and Depressive Symptoms in Late Adulthood: A Cross-Sectional Analysis from a Large Cohort Study
%A Ai Koyanagi
%A Alberto Cester
%A Alberto Vaona
%A Brendon Stubbs
%A Chiara Cacco
%A Francesco Bolzetta
%A Jacopo Demurtas
%A Joseph Firth
%A Lee Smith
%A Marco Solmi
%A Maria Gabriella Caruso
%A Maria Notarnicola
%A Marianna Noale
%A Michele Fornaro
%A Nicola Veronese
%A Rosa Reddavide
%A Stefania Maggi
%A Stefano Celotto
%J Archive of "Nutrients".
%D 2019
%R 10.3390/nu11040787
%X Few studies assessed the associations between dietary vitamin K and depressive symptoms. We aimed to investigate the association between dietary vitamin K and depressive symptoms in a large cohort of North American People. In this cross-sectional analysis, 4,375 participants that were aged 45¨C79 years from the Osteoarthritis Initiative were included. Dietary vitamin K intake was collected through a semi-quantitative food frequency questionnaire and categorized in quartiles. Depressive symptoms were diagnosed using the 20-item Center for Epidemiologic Studies-Depression (CES-D) ¡Ý 16. To investigate the associations between vitamin K intake and depressive symptoms, logistic regression analysis were run, which adjusted for potential confounders. Overall, 437 (=10%) subjects had depressive symptoms. After adjusting for 11 confounders, people with the highest dietary vitamin K intake had lower odds of having depressive symptoms (OR = 0.58; 95%CI: 0.43¨C0.80). This effect was only present in people not taking vitamin D supplementation. In conclusion, higher dietary vitamin K intake was significantly associated with a lower presence of depressive symptoms, also after accounting for potential confounders. Future longitudinal research is required to explore the directionality of the association
%K vitamin K
%K depression
%K Osteoarthritis Initiative
%K mental health
%K diet
%K nutrition
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520944/