%0 Journal Article
%T Inflammatory Dietary Pattern, IL-17F Genetic Variant, and the Risk of Colorectal Cancer
%A Aesun Shin
%A Dae Kyung Sohn
%A Hee Jin Chang
%A Jae Hwan Oh
%A Jeonghee Lee
%A Jeongseon Kim
%A Young Ae Cho
%J Archive of "Nutrients".
%D 2018
%R 10.3390/nu10060724
%X A proinflammatory diet may increase the risk of colorectal cancer, but its role may differ according to individualsĄŻ genetic variants. We aimed to examine whether a specific dietary pattern reflecting inflammation was associated with a risk of colorectal cancer and whether IL-17F genetic variant altered this association. In a study of 695 colorectal cancer cases and 1846 controls, we derived a reduced rank regression dietary pattern using 32 food groups as predictors and the plasma C-reactive protein (CRP) concentration as the response. High CRP levels were associated with a high risk of colorectal cancer (OR (95% CI) = 3.58 (2.65¨C4.82) for the highest quartile vs. lowest quartile). After adjusting for potential confounding factors, high pattern scores were associated with a high risk of colorectal cancer (OR (95% CI) = 9.98 (6.81¨C14.62) for the highest quartile vs. lowest quartile). When stratified by the IL-17F rs763780 genotype, this association was stronger for individuals carrying the C allele (p for interaction = 0.034), particularly for individuals with rectal cancer (p for interaction = 0.011). In conclusion, a dietary pattern reflecting inflammation was significantly associated with colorectal cancer risk. Moreover, this association could be modified according to the IL-17F rs763780 genotype and anatomic site
%K colorectal cancer
%K inflammation
%K C-reactive protein
%K dietary pattern
%K IL-17F polymorphism
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024771/