%0 Journal Article
%T Combining Short-Term Interval Training with Caloric Restriction Improves £¿-Cell Function in Obese Adults
%A Chiara Fabris
%A Emily M. Heiston
%A J. Hunter Mehaffey
%A Marc Breton
%A Monique E. Francois
%A Natalie Z. M. Eichner
%A Nicole M. Gilbertson
%A Peter T. Hallowell
%A Steven K. Malin
%A Taryn Hassinger
%J Archive of "Nutrients".
%D 2018
%R 10.3390/nu10060717
%X Although low-calorie diets (LCD) improve glucose regulation, it is unclear if interval exercise (INT) is additive. We examined the impact of an LCD versus LCD + INT training on £¿-cell function in relation to glucose tolerance in obese adults. Twenty-six adults (Age: 46 ¡À 12 year; BMI 38 ¡À 6 kg/m2) were randomized to 2-week of LCD (~1200 kcal/day) or energy-matched LCD + INT (60 min/day alternating 3 min at 90 and 50% HRpeak). A 2 h 75 g oral glucose tolerance test (OGTT) was performed. Insulin secretion rates (ISR) were determined by deconvolution modeling to assess glucose-stimulated insulin secretion ([GSIS: ISR/glucose total area under the curve (tAUC)]) and £¿-cell function (Disposition Index [DI: GSIS/IR]) relative to skeletal muscle (Matsuda Index), hepatic (HOMA-IR) and adipose (Adipose-IRfasting) insulin resistance (IR). LCD + INT, but not LCD alone, reduced glucose and total-phase ISR tAUC (Interactions: p = 0.04 and p = 0.05, respectively). Both interventions improved skeletal muscle IR by 16% (p = 0.04) and skeletal muscle and hepatic DI (Time: p < 0.05). Improved skeletal muscle DI was associated with lower glucose tAUC (r = £¿0.57, p < 0.01). Thus, LCD + INT improved glucose tolerance more than LCD in obese adults, and these findings relate to £¿-cell function. These data support LCD + INT for preserving pancreatic function for type 2 diabetes prevention
%K caloric restriction
%K diabetes
%K obesity
%K exercise
%K glucose control
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024769/