%0 Journal Article
%T Is Hypovitaminosis D Related to Incidence of Type 2 Diabetes and High Fasting Glucose Level in Healthy Subjects: A Systematic Review and Meta-Analysis of Observational Studies
%A Per Bendix Jeppesen
%A Shamaila Rafiq
%J Archive of "Nutrients".
%D 2018
%R 10.3390/nu10010059
%X There is evidence that vitamin D status is associated with type 2 diabetes. Many observational studies have been performed investigating the relationship of vitamin D status and circulating biomarkers of glycemic regulation. To find out whether this association holds, we conducted a systematic review and meta-analysis of cross sectional and longitudinal studies. We searched Pubmed, Medline and Embase, all through June 2017. The studies were selected to determine the effect of vitamin D on the parameters of glucose metabolism in diabetic and non-diabetic subjects. Correlation coefficients from all studies were pooled in a random effects meta-analysis. The risk of bias was assessed using Grading of Recommendations Assessment, Development and Evaluation (GRADE) system. We found significant inverse relationship of vitamin D status with glycemic level in both diabetic (r = £¿0.223, 95% CI = £¿0.184 to £¿0.261, p = 0.000) and non-diabetic (r = £¿0.073, 95% CI = £¿0.052 to £¿0.093, p = 0.000) subjects. This meta-analysis concludes that hypovitaminosis D is associated with increased risk of hyperglycemia both in diabetic and non-diabetic subjects. A future strategy for the prevention of impaired glycemic regulation could be individualized supplementation of vitamin D
%K 25 (OH) vitamin D
%K Vitamin D
%K Type 2 diabetes
%K hyperglycemia
%K meta-analysis
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793287/