%0 Journal Article
%T Impact of Pre-Pregnancy BMI on B Vitamin and Inflammatory Status in Early Pregnancy: An Observational Cohort Study
%A Anne-Lise Bj£¿rke-Monsen
%A Arve Ulvik
%A Camilla Stoltenberg
%A Christine Roth
%A Per Magne Ueland
%A Per Magnus
%A Roy M. Nilsen
%A Stein Emil Vollset
%A Ted Reichborn-Kjennerud
%A £¿ivind Midttun
%J Archive of "Nutrients".
%D 2016
%R 10.3390/nu8120776
%X Maternal nutrition and inflammation have been suggested as mediators in the development of various adverse pregnancy outcomes associated with maternal obesity. We have investigated the relation between pre-pregnancy BMI, B vitamin status, and inflammatory markers in a group of healthy pregnant women. Cobalamin, folate, pyridoxal 5¡ä-phosphate, and riboflavin; and the metabolic markers homocysteine, methylmalonic acid, and 3-hydroxykynurenine/xanthurenic acid ratio (HK/XA); and markers of cellular inflammation, neopterin and kynurenine/tryptophan ratio (KTR) were determined in pregnancy week 18 and related to pre-pregnancy body mass index (BMI), in 2797 women from the Norwegian Mother and Child Cohort Study (MoBa). Pre-pregnancy BMI was inversely related to folate, cobalamin, pyridoxal 5¡ä-phosphate (PLP), and riboflavin (p < 0.001), and associated with increased neopterin and KTR levels (p < 0.001). Inflammation seemed to be an independent predictor of low vitamin B6 status, as verified by low PLP and high HK/XA ratio. A high pre-pregnancy BMI is a risk factor for low B vitamin status and increased cellular inflammation. As an optimal micronutrient status is vital for normal fetal development, the observed lower B vitamin levels may contribute to adverse pregnancy outcomes associated with maternal obesity and B vitamin status should be assessed in women with high BMI before they get pregnant
%K pregnancy
%K obesity
%K pre-pregnancy BMI
%K B vitamins
%K inflammation
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5188431/