%0 Journal Article
%T HER2 Overexpression in Retinoblastoma: A Potential Therapeutic Target?
%A Ana Beatriz Dias
%A David Cordeiro Sousa
%A Evangelina Esposito
%A Maria Eugenia Orellana
%A Miguel N. Burnier
%A Jr.
%A Pablo Zoroquiain
%J Archive of "Ocular Oncology and Pathology".
%D 2017
%R 10.1159/000455871
%X Retinoblastoma (RB) is the most common primary intraocular malignancy. Current therapies are associated with high morbidity in the short- and long-term. Human epidermal growth factor receptor 2 (HER2) is a transmembrane protein detected in 15¨C30% of breast cancers, but it has also been described in other malignancies. Recently, it has been claimed that a truncated version of this protein is expressed in RB, responsive to directed therapies in vitro. We scored HER2 overexpression in RB tissue samples and discussed its potential clinical utility
%K Retinoblastoma
%K Human epidermal growth factor receptor 2
%K Transmembrane protein
%K Anti-HER2 antibody
%K Immunohistochemistry
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649335/