%0 Journal Article
%T Home Parenteral Nutrition in Patients with Intestinal Failure: Possible Undetected Complications
%A Fabrizio Pasanisi
%A Franco Contaldo
%A Giulio Viceconte
%A Giuseppe De Simone
%A Grazia Tosone
%A Lidia Santarpia
%A Lucia Alfonsi
%A Luigi Camera
%A Maria Carmen Pagano
%A Maria Foggia
%J Archive of "Nutrients".
%D 2019
%R 10.3390/nu11030581
%X Background: Septic pulmonary embolism (SPE) may be a frequently undetected complication of central venous catheter (CVC)-related bloodstream infections (CRBSIs). Materials and Methods: The incidence of SPE was evaluated in a cohort of non-oncological patients on home parenteral nutrition (HPN) who were hospitalized for a CRBSI from January 2013 to December 2017. The main clinical, microbiological, and radiological features and the therapeutic approach were also described. Results: Twenty-three infections over 51,563 days of HPN therapy were observed, corresponding to an infection rate of 0.45/1000. In 10 out of the 23 cases (43.5%), pulmonary lesions compatible with SPE were identified. Conclusion: Our results demonstrated that a CRBSI can produce asymptomatic SPE with lung infiltrates in 43.5% of the cases, suggesting the need to check for secondary lung infections to choose the most appropriate antimicrobial therapy
%K central venous catheter related bloodstream infection
%K home parenteral nutrition
%K septic pulmonary embolism
%K parenteral nutrition
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471421/