%0 Journal Article
%T Tumor-intrinsic oncogene pathways mediating immune avoidance
%A Stefani Spranger
%A Thomas F. Gajewski
%J Archive of "Oncoimmunology".
%D 2016
%R 10.1080/2162402X.2015.1086862
%X Immunotherapy is emerging as a major treatment for patients with cancer, predominantly via blocking immune inhibitory pathways and through adoptive T cell therapy. However, only a subset of patients shows clinical responses to these interventions. Emerging data indicates a correlation between clinical response and a pre-existing T cell-inflamed tumor microenvironment. Tumor-intrinsic ¦Â-catenin activation has been identified as mediating exclusion of T cells from the tumor microenvironment and other oncogene pathways are being explored similarly. Understanding the molecular mechanisms underlying immune avoidance should identify new therapeutic targets for expanding efficacy of immunotherapies
%K Cancer immunotherapy
%K checkpoint blockade
%K non-T cell inflamed tumor
%K T cell infiltration
%K T cell-inflamed tumor
%K tumor immune evasion
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839364/