%0 Journal Article
%T TGF¦Â1 is essential for MSCs-CAFs differentiation and promotes HCT116 cells migration and invasion via JAK/STAT3 signaling
%A Cai-Ling Xiang
%A Hao-Xiang Tan
%A Tao Huang
%A Ting-Ting He
%A Yu Liu
%A Zhen-Bin Cao
%J Archive of "OncoTargets and therapy".
%D 2019
%R 10.2147/OTT.S178618
%X Colorectal cancer (CRC) frequently metastasizes to the liver, which involves the participation of multiple cytokines. Tumor microenvironment (TME) composed of cancer-associated fibroblasts (CAFs) and tumor cells acts as an essential factor in cancer metastasis. Transforming growth factor ¦Â1 (TGF¦Â1) is a vital cytokine involved in migration and invasion of cancer cells. However, the underlying mechanisms remain unclear. In the present study, we aimed to investigate the role and molecular mechanisms of TGF¦Â1 in TME
%K TGF¦Â1
%K JAK/STAT3
%K MSCs-CAFs differentiation
%K migration and invasion
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615717/