%0 Journal Article
%T ROS generation and autophagosome accumulation contribute to the DMAMCL-induced inhibition of glioma cell proliferation by regulating the ROS/MAPK signaling pathway and suppressing the Akt/mTOR signaling pathway
%A Guangming Xu
%A Jiachen Zhang
%A Qi Pang
%A Qian Liu
%A Rui Zhang
%A Yanjun Wang
%A Yihang Yang
%J Archive of "OncoTargets and therapy".
%D 2019
%R 10.2147/OTT.S195329
%X Chemotherapy after surgery can prolong the survival of patients with gliomas. Dimethylaminomicheliolide (DMAMCL), a novel chemotherapeutic agent, exhibited antitumor properties in acute myeloid leukemia stem cells and showed an increased drug concentration in the brain. This study aims to investigate the specific anticancer activities and mechanisms of DMAMCL in glioma cells
%K DMAMCL
%K apoptosis
%K autophagy
%K ROS
%K glioma
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413739/